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Set in the 21st century. A subculture of humans called Hemophages has emerged who have been genetically modified, giving them enhanced speed, incredible stamina and acute intelligence.

To the governments's dismay, more and more of the population are being transformed, and they have set out to rid the world of this new subculture that they deem menaces to society. One rogue warrior is bent on protecting her race - and seeking revenge on those who changed her life forever.

With fierce fighting skills and chameleon-like abilities, Violet (Milla Jovovich) sets out to destroy a governments-designed time bomb that will eliminate all Hemophages. To Violet's surprise, the deadly device is a nine-year-old boy, who was raised in a laboratory and goes by the name Six (Cameron Bright).